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FOXO4-DRI is a senolytic peptide a D-retro-inverso peptide engineered to selectively eliminate senescent "zombie" cells that accumulate with age and secrete inflammatory factors (the senescence-associated secretory phenotype, or SASP)

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Although it was originally developed to suppress oncogenic transcription factors such as androgen receptor and MYC, recent findings have shown that CCS1477 also effectively represses NRF2-dependent cytoprotective gene expression, which plays a central role in chemoresistance and immune evasion in KEAP1-mutant cancers [323]